Probabilistic graphical modeling (PGM) provides a framework for formulating an interpretable generative process of data and expressing uncertainty about unknowns, but it lacks flexibility. Deep learning (DL) is an alternative framework for learning from data that has achieved great empirical success in recent years. DL offers great flexibility, but it lacks the interpretability and calibration of PGM. This thesis develops deep probabilistic graphical modeling (DPGM.) DPGM consists in leveraging DL to make PGM more flexible. DPGM brings about new methods for learning from data that exhibit the advantages of both PGM and DL. We use DL within PGM to build flexible models endowed with an interpretable latent structure. One model class we develop extends exponential family PCA using neural networks to improve predictive performance while enforcing the interpretability of the latent factors. Another model class we introduce enables accounting for long-term dependencies when modeling sequential data, which is a challenge when using purely DL or PGM approaches. Finally, DPGM successfully solves several outstanding problems of probabilistic topic models, a widely used family of models in PGM. DPGM also brings about new algorithms for learning with complex data. We develop reweighted expectation maximization, an algorithm that unifies several existing maximum likelihood-based algorithms for learning models parameterized by neural networks. This unifying view is made possible using expectation maximization, a canonical inference algorithm in PGM. We also develop entropy-regularized adversarial learning, a learning paradigm that deviates from the traditional maximum likelihood approach used in PGM. From the DL perspective, entropy-regularized adversarial learning provides a solution to the long-standing mode collapse problem of generative adversarial networks, a widely used DL approach.

Generative adversarial networks (GANs) are a powerful approach to unsupervised learning. They have achieved state-of-the-art performance in the image domain. However, GANs are limited in two ways. They often learn distributions with low support---a phenomenon known as mode collapse---and they do not guarantee the existence of a probability density, which makes evaluating generalization using predictive log-likelihood impossible. In this paper, we develop the prescribed GAN (PresGAN) to address these shortcomings. PresGANs add noise to the output of a density network and optimize an entropy-regularized adversarial loss. The added noise renders tractable approximations of the predictive log-likelihood and stabilizes the training procedure. The entropy regularizer encourages PresGANs to capture all the modes of the data distribution. Fitting PresGANs involves computing the intractable gradients of the entropy regularization term; PresGANs sidestep this intractability using unbiased stochastic estimates. We evaluate PresGANs on several datasets and found they mitigate mode collapse and generate samples with high perceptual quality. We further found that PresGANs reduce the gap in performance in terms of predictive log-likelihood between traditional GANs and variational autoencoders (VAEs).